Signal enhancement techniques for rf SQUID based magnetic imaging systems
نویسندگان
چکیده
We have investigated the rf SQUID (radio-frequency superconducting quantum interference device) and its coupling to tank circuit configurations to achieve an optimal front-end assembly for sensitive and high spatial resolution magnetic imaging systems. The investigation of the YBCO rf SQUID coupling to the conventional LC tank circuits revealed that coupling from the back of the SQUID substrate enhances the SQUID signal while facilitating the front-end assembly configuration. The optimal thickness of the substrate material between the SQUID and the tank circuit is 0.4 mm for LaAlO3 resulting in an increase of the SQUID flux–voltage transfer function signal, Vspp, of 1.5 times, and 0.5 mm for SrTiO3 with an increase of Vspp of 1.62 times compared to that for direct face to face couplings. For rf coupling with a coplanar resonator, it has been found that the best configuration, in which a resonator is sandwiched between the SQUID substrate and the resonator substrate, provides a Vspp about 3.4 times higher than that for the worse case where the resonator and the SQUID are coupled back to back. The use of a resonator leads to a limitation of the achievable spatial resolution due to its flux focusing characteristics. This resulted in a favouring of the use of the conventional tank circuits when considering the desired high spatial resolution. The effect of the YBCO flip chip magnetic shielding of the SQUIDs in the back-coupling with the LC tank circuit configuration has also been investigated, with a view to reducing the SQUID effective area to increase the spatial resolution and also for studying the effect of the coupling of various kinds of transformers to the SQUIDs. It is revealed that there is no very considerable change in the flux–voltage transfer function signal level with respect to the effective shield area, while the lowest working temperature of the SQUIDs was slightly shifted higher by a couple of degrees, depending on the shield area. (Some figures in this article are in colour only in the electronic version)
منابع مشابه
Microtesla MRI with dynamic nuclear polarization.
Magnetic resonance imaging at microtesla fields is a promising imaging method that combines the pre-polarization technique and broadband signal reception by superconducting quantum interference device (SQUID) sensors to enable in vivo MRI at microtesla-range magnetic fields similar in strength to the Earth magnetic field. Despite significant advances in recent years, the potential of microtesla...
متن کاملPerfusion-based functional magnetic resonance imaging with single-shot RARE and GRASE acquisitions.
For perfusion-based functional magnetic resonance imaging, the previously introduced flow-sensitive alternating inversion recovery (FAIR) technique is combined with single-shot RARE (rapid acquisition with relaxation enhancement) and GRASE (gradient and spin echo) imaging sequences. The advantages of these sequences compared to commonly used echo-planar imaging (EPI) are an increased signal-to-...
متن کاملEnhancement of SQUID-detected NMR signals with hyperpolarized liquid 129Xe in a 1 microT magnetic field.
We report an enhancement of proton NMR signals by a factor of 10(6) by cross polarization with hyperpolarized liquid 129Xe in an ultralow magnetic field of 1 microT. The NMR signals from cyclopentane, acetone, and methanol are detected using a commercial high-T(c) SQUID magnetometer with a signal-to-noise ratio of up to 1000 from a single 90 degrees tipping pulse. This technique allows a wide r...
متن کاملThe set-up of an high temperature superconductor radio-frequency SQUID microscope for magnetic nanoparticle detection
SQUID (superconducting quantum interference device) microscopes are versatile instruments for biosensing applications, in particular for magnetic nanoparticle detection in immunoassay experiments. We are developing a SQUID microscope based on an HTS rf SQUID magnetometer sensor with a substrate resonator. For the cryogenic set-up, a configuration was realized in which the cryostat is continuous...
متن کاملDetection of Her2 Levels in Cancerous Cells Based on Iron Oxide Nanoparticles
In this study, we synthesized Herceptin conjugated magnetic nanoparticles (HMNs) as an alternative probe to discover the levels of HER2 (Human epidermal growth factor receptor-2) in the surface of cells. These nanoparticles can be used by magnetic resonance imaging (MRI) (non-invasive methods) for screening the patients with HER2 positive or negative tumors. Dextran coated iron oxide nanopartic...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2006